During Biochemistry Integrative lab, students are asked to work in teams to brainstorm and create analogs of Cisplatin, a platinum based chemotherapeutic that is very prevalent in the clinic. Unfortunately, Cisplatin therapy can result in some annoying or even dangerous side effects ranging from tinnitus to nephrotoxicity. The four student authors created and synthesized an ethylenediamine-coordinated Platinum complex, and an ethylenediamine-coordinated Palladium complex, among others, and characterized it. They tested the drugs in live cancer cell line culture and compared the data to the native Cisplatin. They were encouraged by their faculty mentors, Drs Burkett and Dwyer, to collate the data and sumbit it for publication. Their paper finally appears in the December 2022 issue of AJUR Volume 19 Issue 3. Congratulations to these first-time authors!
ABOUT STUDENT AUTHORS
Samantha Rea and Brooke Hornberger graduated with their B.S. in Biochemistry Degree in December 2021, while Alexia Smith and Grace Fillmore graduated with their B.S. in Biochemistry Degree in May 2022.