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Tracey McGregor Mason , Ph.D.

Professor
Chemistry | Fine School of the Sciences
Tracey Mason
Contact
443-394-9661
Office Hours
Varies by semester, but always by appointment.
Office Location

Kevin J. Manning Academic Center 

Room N108

Owings Mills North Campus

Campus Map

Education

Ph.D. in Bioinorganic Chemistry, Virginia Commonwealth University, Richmond, VA (2001)

B.A. in Chemistry, Longwood College (now University), Farmville, VA (1991)

Professional Experience

Stevenson University

Professor of Chemistry
2017-present

Associate Professor of Chemistry
2014-2017

Assistant Professor of Chemistry
2008-2014

Johns Hopkins University Bloomberg School of Public Health
Postdoctoral Fellow, Department of Biochemistry and Molecular Biology
2002-2007

University of Maryland Baltimore County
Postdoctoral Research Associate, Department of Chemistry and Biochemistry
2001-2002

United States Peace Corps
Secondary Science Education Volunteer, Fiji
1994-1996

Research

                                     

Despite developments in novel cancer therapies, Cisplatin is often the initial therapy administered for a variety of tumors. Unfortunately, innate or acquired Cisplatin resistance is a very real problem. Trans platinum complexes have classically been dismissed at ineffective, but modifications to the classical diammine/ dichloro motif have produced some promising trans candidates. In collaboration with Dr. Adoracion Quiroga of the University of Madrid, we are attempting to characterize the mechanism of action of trans- isopropylamine-triphenylphosphine diiodine Pt(II). We have assayed the cytotoxicity, cell cycle and apoptosis of this complex in several human cell lines, some with Cisplatin resistance.  Future work includes Pt uptake and interstrand cross-linking.

Publications

Kasper, C., Schneidereith, T.A. & Lashley, Felica R.  (2015). Chapter 4: Inheritance Patterns in Human Phenotypes and Types of Genetic Disorders In Timothy M. Dwyer, Rivka L. Glaser & Tracey M. Mason (Eds.), Lashley’s Essentials of Clinical Genetics in Nursing Practice, 2nd  Edition. New York, Springer Publishing Company, LLC. ISBN: 978-0-8261-2912-3

 

M. A. Medrano, S.M. Dennis, A. Alvarez-Valdés, J. Perles, T.M. Mason and A. G. Quiroga. Synthesis, cytotoxicity, DNA interaction and cell cycle studies of trans-diiodophosphine Pt (II) complexes. Dalton Transactions, 44(8):  3557-62 (2015) PMID: 25310702

 

Michael B. Smeaton, Erica M. Hlavin, Tracey McGregor Mason, Christopher J. Wilds, Anne M. Noronha, Paul S. Miller. Distortion-dependent unhooking of interstrand cross-links in mammalian cell extracts. Biochemistry, 47:  9920-30 (2008).  PMID: 8702509

 

T. M. Mason, M. Smeaton, J. Cheung, L. Hanakahi, and P. Miller. End modification of a linear DNA duplex enhances NER-mediated excision of an internal Pt(II)-lesion. Bioconjugate Chemistry, 19: 1064-70 (2008) PMID: 18447369

 

M. Campbell, T. M. Mason, and P. Miller. Interactions of Platinum (II) Derivatized Triplex Forming Oligonucleotides with DNA. Canadian Journal of Chemistry, 85:  241-248 (2007) doi:10.1139/V07-016

 

D. M. Noll, T. M. Mason, P. S. Miller. Formation and Repair of Interstrand Cross-links in DNA. Chemical Reviews, 106: 277 -301 (2006) PMID: 16464006

 

T. D. McGregor, W. Bousfield, Y. Qu, N.Farrell. Irreversibility of Conformational Changes in DNA as Induced by Polynuclear Platinum Compounds. Journal of Inorganic Biochemistry, 91: 212-9. (2002) PMID: 12121778

 

T. D. McGregor, J. Kašpárková, K. Neplechová, O. Nováková, H. Penazová, O. Vrána, V. Brabec, and N. Farrell. A Comparison of DNA Binding Profiles of Dinuclear Platinum Compounds with Polyamine Linkers and a Trinuclear Platinum Phase II Clinical Agent. Journal of Biological Inorganic Chemistry. 4-5: 397-404. (2002) PMID: 11941497

 

T. D. McGregor, Z. Balcarová, Y. Qu, M. Tran, R. Zaludová, V. Brabec, and N. Farrell. Sequence-Dependent Conformational Changes in DNA Induced by Polynuclear Platinum Complexes. Journal of Inorganic Biochemistry, 77: 43-6. (1999) PMID: 10626352

Teaching

Primary Courses

Bioch/Chem and Forensic Science Research and Internship Capstone

Chem 310: Analytical Chemistry

Chem 346L: Integrative Laboratory

Chem 410: Instrumental Analysis with Laboratory

Bioch/Chem 365: Independent Laboratory Research 

FYS 100: First Year Seminar

Chem 213: Digital Literacy in Chemistry

 

Courses also taught as needed 

Chem 115: General Chemistry I

Chem 115L: General Chemistry I Laboratory

Chem 116L: General Chemistry II Laboratory

Chem 210: Organic Chemistry I

Chem 210L: Organic Chemistry I Laboratory

Chem 211: Organic Chemistry II

Chem 211L: Organic Chemistry II Laboratory

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