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Tracey Mason: Fine School of the Sciences Faculty
Tracey McGregor Mason , Ph.D.
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Education
Ph.D. in Bioinorganic Chemistry, Virginia Commonwealth University, Richmond, VA (2001)
B.A. in Chemistry, Longwood College (now University), Farmville, VA (1991)
Professional Experience
Stevenson University
Graduate Program Director MFS/CSI and Professor of Chemistry
2020-present
Professor of Chemistry
2017-2020
Associate Professor of Chemistry
2014-2017
Assistant Professor of Chemistry
2008-2014
Johns Hopkins University Bloomberg School of Public Health
Postdoctoral Fellow, Department of Biochemistry and Molecular Biology
2002-2007
University of Maryland Baltimore County
Postdoctoral Research Associate, Department of Chemistry and Biochemistry
2001-2002
United States Peace Corps
Secondary Science Education Volunteer, Fiji
1994-1996
Research
Despite developments in novel cancer therapies, Cisplatin is often the initial therapy administered for a variety of tumors. Unfortunately, innate or acquired Cisplatin resistance is a very real problem. Trans platinum complexes have classically been dismissed at ineffective, but modifications to the classical diammine/ dichloro motif have produced some promising trans candidates. In collaboration with Dr. Adoracion Quiroga of the University of Madrid, we are attempting to characterize the mechanism of action of trans- isopropylamine-triphenylphosphine diiodine Pt(II). We have assayed the cytotoxicity, cell cycle and apoptosis of this complex in several human cell lines, some with Cisplatin resistance. Future work includes Pt uptake and interstrand cross-linking.
Publications
Kasper, C., Schneidereith, T.A. & Lashley, Felica R. (2015). Chapter 4: Inheritance Patterns in Human Phenotypes and Types of Genetic Disorders In Timothy M. Dwyer, Rivka L. Glaser & Tracey M. Mason (Eds.), Lashley’s Essentials of Clinical Genetics in Nursing Practice, 2nd Edition. New York, Springer Publishing Company, LLC. ISBN: 978-0-8261-2912-3
M. A. Medrano, S.M. Dennis, A. Alvarez-Valdés, J. Perles, T.M. Mason and A. G. Quiroga. Synthesis, cytotoxicity, DNA interaction and cell cycle studies of trans-diiodophosphine Pt (II) complexes. Dalton Transactions, 44(8): 3557-62 (2015) PMID: 25310702
Michael B. Smeaton, Erica M. Hlavin, Tracey McGregor Mason, Christopher J. Wilds, Anne M. Noronha, Paul S. Miller. Distortion-dependent unhooking of interstrand cross-links in mammalian cell extracts. Biochemistry, 47: 9920-30 (2008). PMID: 8702509
T. M. Mason, M. Smeaton, J. Cheung, L. Hanakahi, and P. Miller. End modification of a linear DNA duplex enhances NER-mediated excision of an internal Pt(II)-lesion. Bioconjugate Chemistry, 19: 1064-70 (2008) PMID: 18447369
M. Campbell, T. M. Mason, and P. Miller. Interactions of Platinum (II) Derivatized Triplex Forming Oligonucleotides with DNA. Canadian Journal of Chemistry, 85: 241-248 (2007) doi:10.1139/V07-016
D. M. Noll, T. M. Mason, P. S. Miller. Formation and Repair of Interstrand Cross-links in DNA. Chemical Reviews, 106: 277 -301 (2006) PMID: 16464006
T. D. McGregor, W. Bousfield, Y. Qu, N.Farrell. Irreversibility of Conformational Changes in DNA as Induced by Polynuclear Platinum Compounds. Journal of Inorganic Biochemistry, 91: 212-9. (2002) PMID: 12121778
T. D. McGregor, J. Kašpárková, K. Neplechová, O. Nováková, H. Penazová, O. Vrána, V. Brabec, and N. Farrell. A Comparison of DNA Binding Profiles of Dinuclear Platinum Compounds with Polyamine Linkers and a Trinuclear Platinum Phase II Clinical Agent. Journal of Biological Inorganic Chemistry. 4-5: 397-404. (2002) PMID: 11941497
T. D. McGregor, Z. Balcarová, Y. Qu, M. Tran, R. Zaludová, V. Brabec, and N. Farrell. Sequence-Dependent Conformational Changes in DNA Induced by Polynuclear Platinum Complexes. Journal of Inorganic Biochemistry, 77: 43-6. (1999) PMID: 10626352
Teaching
Primary Courses
Bioch/Chem and Forensic Science Research and Internship Capstone
Chem 310: Analytical Chemistry
Chem 346L: Integrative Laboratory
Chem 435: Special Topic in Instrumental Analysis
Bioch/Chem 365: Independent Laboratory Research
FYS 100: First Year Seminar
Chem 213: Digital Literacy in Chemistry
MLS 325L :Clinical Chemistry Laboratory
Courses also taught as needed
Chem 115: General Chemistry I
Chem 115L: General Chemistry I Laboratory
Chem 116L: General Chemistry II Laboratory
Chem 210: Organic Chemistry I
Chem 210L: Organic Chemistry I Laboratory
Chem 211: Organic Chemistry II
Chem 211L: Organic Chemistry II Laboratory
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