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Tracey McGregor Mason
Contact
443-394-9661
Office Hours

Varies by semester, but always by appointment.

Tracey McGregor Mason Ph.D.

Professor
Chemistry | Fine School of the Sciences

Education

  • Ph.D. in Bioinorganic Chemistry, Virginia Commonwealth University, Richmond, VA (2001)
  • B.A. in Chemistry, Longwood College (now University), Farmville, VA (1991)

Professional Experience

  • Stevenson University
    Graduate Program Director MFS/CSI and Professor of Chemistry 2020-present
    Professor of Chemistry 2017-2020
    Associate Professor of Chemistry 2014-2017
    Assistant Professor of Chemistry 2008-2014
  • Johns Hopkins University Bloomberg School of Public Health Postdoctoral Fellow, Department of Biochemistry and Molecular Biology 2002-2007
  • University of Maryland Baltimore County Postdoctoral Research Associate, Department of Chemistry and Biochemistry 2001-2002
  • United States Peace Corps Secondary Science Education Volunteer, Fiji 1994-1996

Research

Despite developments in novel cancer therapies, Cisplatin is often the initial therapy administered for a variety of tumors. Unfortunately, innate or acquired Cisplatin resistance is a very real problem. Trans platinum complexes have classically been dismissed at ineffective, but modifications to the classical diammine/ dichloro motif have produced some promising trans candidates. In collaboration with Dr. Adoracion Quiroga of the University of Madrid, we are attempting to characterize the mechanism of action of trans– isopropylamine-triphenylphosphine diiodine Pt(II). We have assayed the cytotoxicity, cell cycle and apoptosis of this complex in several human cell lines, some with Cisplatin resistance. Future work includes Pt uptake and interstrand cross-linking.

Publications

  • Kasper, C., Schneidereith, T.A. & Lashley, Felica R. (2015). Chapter 4: Inheritance Patterns in Human Phenotypes and Types of Genetic Disorders In Timothy M. Dwyer, Rivka L. Glaser & Tracey M. Mason (Eds.), Lashley’s Essentials of Clinical Genetics in Nursing Practice, 2nd Edition. New York, Springer Publishing Company, LLC. ISBN: 978-0-8261-2912-3
  • M. A. Medrano, S.M. Dennis, A. Alvarez-Valdés, J. Perles, T.M. Mason and A. G. Quiroga. Synthesis, cytotoxicity, DNA interaction and cell cycle studies of trans-diiodophosphine Pt (II) complexes. Dalton Transactions, 44(8): 3557-62 (2015) PMID: 25310702
  • Michael B. Smeaton, Erica M. Hlavin, Tracey McGregor Mason, Christopher J. Wilds, Anne M. Noronha, Paul S. Miller. Distortion-dependent unhooking of interstrand cross-links in mammalian cell extracts. Biochemistry, 47: 9920-30 (2008). PMID: 8702509
  • T. M. Mason, M. Smeaton, J. Cheung, L. Hanakahi, and P. Miller. End modification of a linear DNA duplex enhances NER-mediated excision of an internal Pt(II)-lesion. Bioconjugate Chemistry, 19: 1064-70 (2008) PMID: 18447369
  • M. Campbell, T. M. Mason, and P. Miller. Interactions of Platinum (II) Derivatized Triplex Forming Oligonucleotides with DNA. Canadian Journal of Chemistry, 85: 241-248 (2007) doi:10.1139/V07-016
  • D. M. Noll, T. M. Mason, P. S. Miller. Formation and Repair of Interstrand Cross-links in DNA. Chemical Reviews, 106: 277 -301 (2006) PMID: 16464006
  • T. D. McGregor, W. Bousfield, Y. Qu, N.Farrell. Irreversibility of Conformational Changes in DNA as Induced by Polynuclear Platinum Compounds. Journal of Inorganic Biochemistry, 91: 212-9. (2002) PMID: 12121778
  • T. D. McGregor, J. Kašpárková, K. Neplechová, O. Nováková, H. Penazová, O. Vrána, V. Brabec, and N. Farrell. A Comparison of DNA Binding Profiles of Dinuclear Platinum Compounds with Polyamine Linkers and a Trinuclear Platinum Phase II Clinical Agent. Journal of Biological Inorganic Chemistry. 4-5: 397-404. (2002) PMID: 11941497
  • T. D. McGregor, Z. Balcarová, Y. Qu, M. Tran, R. Zaludová, V. Brabec, and N. Farrell. Sequence-Dependent Conformational Changes in DNA Induced by Polynuclear Platinum Complexes. Journal of Inorganic Biochemistry, 77: 43-6. (1999) PMID: 10626352

Teaching

Primary Courses

  • Bioch/Chem and Forensic Science Research and Internship Capstone
  • Chem 310: Analytical Chemistry
  • Chem 346L: Integrative Laboratory
  • Chem 435: Special Topic in Instrumental Analysis
  • Bioch/Chem 365: Independent Laboratory Research
  • FYS 100: First Year Seminar
  • Chem 213: Digital Literacy in Chemistry
  • MLS 325L :Clinical Chemistry Laboratory

Courses also taught as needed

  • Chem 115: General Chemistry I
  • Chem 115L: General Chemistry I Laboratory
  • Chem 116L: General Chemistry II Laboratory
  • Chem 210: Organic Chemistry I
  • Chem 210L: Organic Chemistry I Laboratory
  • Chem 211: Organic Chemistry II
  • Chem 211L: Organic Chemistry II Laboratory

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